CAESAR-ALE: An Active Learning Enhancement for Conditions Severity Classification

Nir Nissim, Mary Regina Boland, Robert Moskovitch, Nicholas Tatonetti, Yuval Elovici, Yuval Shahar, George Hripcsak

Conference on Artificial Intelligence in Medicine in Europe AIME 2015: Artificial Intelligence in Medicine pp 13-24

Understanding condition severity, as extracted from Electronic Health Records (EHRs), is important for many public health purposes. Methods requiring physicians to annotate condition severity are time-consuming and costly. Previously, a passive learning algorithm called CAESAR was developed to capture severity in EHRs. This approach required physicians to label conditions manually, an exhaustive process. We developed a framework that uses two Active Learning (AL) methods (Exploitation and Combination_XA) to decrease manual labeling efforts by selecting only the most informative conditions for training. We call our approach CAESAR-Active Learning Enhancement (CAESAR-ALE). As compared to passive methods,CAESAR-ALE’s first AL method, Exploitation, reduced labeling efforts by 64% and achieved an equivalent true positive rate, while CAESAR-ALE’s second AL method, Combination_XA, reduced labeling efforts by 48% and achieved equivalent accuracy. In addition, both these AL methods outperformed the traditional AL method (SVM-Margin). These results demonstrate the potential of AL methods for decreasing the labeling efforts of medical experts, while achieving greater accuracy and lower costs.